I always found the Co-Pilot somewhat appealing, but never seriously considered it for myself -- until now.
I'm making some relatively big changes to the things I pack when I travel (I travel frequently for work, flying out for a week at a time), which is a perfect time to re-evaluate my bags to make sure they best suit my needs. And I'm suddenly taking a close look at bags like the Co-Pilot and the Synapse that I had never even slightly considered before.
When I'm not on the road, I work from home, so an Everyday Carry bag is only an occasional thing for me, but the Co-Pilot is definitely in the running for that spot. (I love that it stores a water bottle in the center rather than off to the side.)