I vacation-tested the Aeronaut and Imago along with the custom packing cubes on my recent trip to Montreal. (Photo attached, had a great time, thanks.) Thanks to the evil JFK airport, I spent a lot more time with this bag on my back than I intended to, and can report that it's remarkably comfortable even when one is dog-tired and at the end of their rope. (Other photo is of me in the comparatively lovely Philly airport.) Also, those handle-thingys on the sides are really, really brilliant when dragging the bag in and out of planes, trains, and automobiles. I was amused to catch my cabbie checking out my bag admiringly.
We flew on tiny airplanes, so tiny that even the Aeronaut doesn't fit in the overhead. The flight crew made most people relinquish bags to the cargo hold, but let me carry my Aeronaut on to the plane every time. In comparison, my boyfriend's flight case is an older one that is not all bloated with expandable compartments, and is therefore about the same size as the Aeronaut. I blame this discrepancy on the Aeronaut being a backpack, the lack of wheels, and the sleek design.