Since a few folks have asked, here are some comparison photos between a Deep Blue/Coyote Synik 30 and an Original/Island Aeronaut 30.
TL/DR: Same stuff fit in both bags, just a bit easier in the A30. Maximizing the Synik space means using all the pockets well. If you've been craving clamshell & built in laptop and/or love single-bag travel, you'll like the Synik family. If you've been fine with the Synapses and Aeronauts, it may not be worth getting another bag...
I packed a generic bunch of non-winter stuff I would bring on a trip lasting a week or so, assuming a bit of washing. None of the cubes were jammed pack, as that's not how I like to pack.
Starting on the left:
Island A30 Small Laundry Cube : workout pants & shirt; sleep shirt & shorts
NWSky A30 Small Laundry Cube : 5 short sleeved shirts (2 cotton; 3 synth)
Wasabi A30 Small Laundry Cube : 7 prs undies; 1 bra; 2 prs wool socks
Eagle Creek shoe sack: 1 pr workout shoes
1 pr folded jeans
Fjord Small Snake Charmer: lightly packed with a mouse; phone charger; laptop powerbrick
Dawn Clear 3DOC : wet toiletries
Kiwi 'The Kit' (disco'd) : dry toiletries, comb, etc.
HP Pavilion laptop
Original 3DOC : the random stuff I usually keep in my EDC (pens, quarters, duct tape, bandaids, etc)
Island Travel Cubelet : my 'portable office' with checkbooks, notebook, pens, stamps, etc.
In the Synik:
'The Kit' and Clear 3DOC in two side pockets
3DOC, TC, and SSC in the chin pocket
jeans flat, EC cube of shoes at the bottom, thickest Laundry Cube, then the remaining two stacked on top of each other
laptop in the built-in compartment... my MacBook Air (larger 2013 version) also fits
total weight was about 17.5 lbs, with the bag
In the A30:
'The Kit' and SSC in the left/top pocket, divider wall unzipped to make laptop easier
jeans flat, 3 Laundry Cubes & Clear 3DOC in main compartment
laptop on top - normally I'd have it in a neoprene sleeve, but I forgot to bring it home, there was definitely room for it to fit
EC cube of shoes, 3DOC, & TC in the right/bottom pocket... the 3DOC or TC also would fit in the main compartment
The Syniks are a cool design that add a few features to the Synapses that many folks have been clamoring for. They're built with the expected Tom Bihn attention to detail and quality. These are fine bags that will make many folks happy.
For me, they are solving problem(s) that I don't actually have. I use neoprene sleeves for my laptops and don't particularly care about the clamshell.
I like my Synapse 19s a lot...unfortunately neither my work nor personal laptop will fit in the Synik 22 sleeve - I would still have to use my neoprene sleeves - though the couple extra liters is nice.
I find the A30 easier to pack and more comfortable to carry than the SN30, but I'm also more used to it, so time will tell. Whilst I haven't traveled with the SN30 yet (only EDC), I am sure the A30 is easier to 'live out of' just due to the access/design.
Once we get into the S25 and SN30, the backpack lengths are just over my torso length, so I don't find either of them as comfortable as the shorter packs.
Usually I travel with a main bag on my back and a small bag for under the seat. I don't particularly feel the need to single-bag travel though I have done so.
If I had the type of trip where I needed a laptop and also needed to haul my stuff around with me for large chunks of the days, multiple transport modes, etc., I would single-bag it. It never bothered me to use a Synapse or the Smart Alec for that use case though - I just use neoprene sleeves for the laptop(s).
Like every other bag, whether you will like the Syniks will depend on how you like to pack and travel... hopefully this has provided another data point for you to consider.
ETA: thanks to @aedifica for telling me about the 'Be Funky' free collage maker to help with the photos, tho I still don't have mad skills there yet
I'll be traveling next weekend for 3 nights - I'll take the SN30 with both laptops, clothes for the trip, etc. as a single bag trip & report back.